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Questions for Dr. Kennedy
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Mercury Toxicity / Chronic Gut Wall Infection
Posted by: Jordan
Date: February 5, 2004 7:04 PM

I am a 22 year old male, about 6’0, and 160 lbs. In March of 2001, I was dealing with a case of acne, and was prescribed the controversial drug Acutane to see if it would clear up my skin. After taking the drug for 3-1/2 months, my skin was pretty well clear, and I was thrilled. I had only one month left to complete the treatment, and then I would be home free. With about 2 weeks left in the treatment however, I began to notice that I was developing some odd looking skin lesions or hives. They grew in number and in size with each day, and they would itch and burn a great deal. With one week to go on my treatment, I decided that maybe I had enough of the wonder drug, and it would be time to give it a rest. I discontinued the treatment, and sure enough my hives disappeared leaving me once again content. In late August 2001 after about 3 weeks of being off Acutane, I began to notice some hives appearing on my skin after hot showers or if I felt my skin being a little dry. I chalked it up to the backlash effects of being on Acutane and didn’t pay much attention to it for the first month, thinking it would just go away. After this month however, I began to experience other side effects which were unexpected. I woke up one morning without my usual morning erection and, at the risk of sounding parochial, and for a lack of ability to explain it any better, I felt as if I had lost my mojo. Not just in a sexual sense, but I just did not feel like myself. Before I knew it, I was so fatigued and congested and it felt as if I had the flu 24 hours a day every day, complete with cold hands and feet, plus chronic hives and a combination of erectile dysfunction and severely decreased libido. I went to see my GP, and he advised me to have a complete blood test. My blood test results at that time revealed an elevated TSH as well as some trouble with my liver. After adjusting my diet and cutting back on a typical 22 year old lifestyle which included plenty of partying, I returned to my GP’s office 2 months later to do a new set of blood tests, even though I experienced no functional improvement whatsoever. My new blood results showed that my liver had come back to the ‘normal’ range, but my TSH was still high. At this point, I decided to seek the opinion of the on-site endocrinologist. Needless to say, I was still at a point then when I was quite uneducated as it relates to the endocrine system, and I trusted the words of a certified endocrinologist. In April of 2002, I began taking Synthroid at a dosage of .075, with the hopes that within a few weeks my symptoms would disappear. After about 2 months, I still saw no improvement whatsoever and grew frustrated. In May 2002, I went to see an ENT specialist because of my congestion problems and he prescribed me a week’s supply of Prednisone to help with polyps I had apparently developed in my sinuses (these polyps were noticed when x-rays were conducted in a sleep apnea clinic, which I went to thanks to my lack of quality sleep). After taking the very first pill of Prednisone at a dosage of 50 mg, my hives improved to about 75% what I would deem as clear or normal, and I obviously liked the change for the better. I ended up getting refills and staying on smaller doses of Prednisone for the next 2 months. Once coming off the prednisone, my hives worsened to their original state of disturbance and I was back to square one. Fast forwarding 3 months now, we are in about October 2002, and I was still experiencing the same slew of symptoms I had been experiencing since September 2001, when this all started, and so I chose to discontinue Synthroid, feeling it was not the way to go. I decided that I needed to speak with a reputable endocrinologist and so I was referred to a so-called expert. It was then that I did blood tests that revealed that my TSH was within the normal range, and everything seemed to be “normal.” I began to grow discouraged and did not know where to turn for assistance. This condition was not improving in the least, and it was beginning to consume my every thought. At some point around this time, I took my temperature one morning just to see what it was at, and noticed that it was at 96.9. This seemed odd and so I asked my GP about it, and he said it could be hypometabolism. To this day, I take my temperature several times a day almost every day and I have never seen higher than 97.3 since that day. Who knows how long before then it had been that low. Anyhow, it was also around this time that I began to learn about a condition called Wilson’s Thyroid Syndrome. In March of 2003, I was pointed in the holistic direction. I began to see a naturopathic doctor and it was at her office where she did a test with me where I would hold a metallic conductor in my right hand, while she aims a conductive pointer at different points on my fingers and toes to reveal imbalances in the body. This machine revealed that I was experiencing some trouble with my adrenal as well as my thyroid gland. The following week, in April of 2003, I traveled with my parents to a reputable center for complementary medicine and it was there that I did a series of blood tests that revealed a slightly elevated level of Reverse T3 in my body. In a range of 90-350, I had a Reverse T3 level of 363. pg/ml. In addition, I tested low for DHEA, as in a range of 280-640, I had a result of 242 ug/dl. These results led me to believe that my hormonal imbalances could be intertwined, but I could not pinpoint precisely what was going on. I began at this point to take a wide variety of supplements provided to me by my naturopath, including various “adrenal extract supplements.”. In May 2003, I decided to try Wilson’s time released T3 Protocol. As it turned out, over the next 5 months, I went through 5 full cycles of going up to 90 mcg twice daily without any improvement or signs of change! I did another series of blood tests and this time my RT3 was in the higher end of the normal range. Nothing seemed to make any sense to me. About two months ago, I decided to take a step back and forget about WTS for a moment and focus on the one condition I clearly suffer from; hypometabolism. I read about the relationship between mercury toxicity and hypometabolism, and taking into account the high amount of fish, sushi, etc that I consume on a regular basis, thought it could be relevant and decided to have tests done. I did a DMSA challenge test, and my results indicated that I had an extremely toxic level of mercury in my body (‘normal’ was considered less than 3, and I was at 9.7). I immediately had my amalgams removed (only 2), and was set for recovery. With this information came new hope, which almost brings me to today and my questions for you. I have been treating my mercury toxicity by taking 250 mg of DMSA twice daily for 3 days, and then staying off of it for 5 days and repeating this cycle. I have gone through 3 cycles so far (18 pills), and have yet to see improvement. Do you think my dosage should be adjusted? Am I being too impatient in thinking this might not work? How long might I have to continue this treatment before I see results? Also, as you mentioned on your site, leaky gut infection also can result and I think I may have this as well, as I go to the bathroom 3 times a day at least and am often bloated. Are my main symptoms that I complain about (hives, erectile dysfunction, cold hands and feet, congestion, fatigue) caused by the mercury or by the gut wall infection? Also, I know you feel that treatment without penicillamine is inadequate. Why is that, because as far as I have heard from my doctors, DMSA also crosses the blood brain barrier. Dr. Kennedy, I only discovered your site now, but I wish that I had months ago, as you provide people with a forum in which they can help others and themselves conjunctively. Thank you so much for your time and effort, it means a lot more to me than you could know.

RE: Mercury Toxicity / Chronic Gut Wall Infection
Posted by: Ron Kennedy, M.D.,
Date: February 7, 2004 1:47 PM

You have already discovered most of what I would tell you - namely that your gut is damaged and your digestion is not only impaired but that you are probably receiving doses of large proteins in the undigested form into your system (provoking your immune system and producing hives). The factors which can damage the gut in that fashion are prolonged antibiotics, heavy metal toxicity (particularly mercury), prolonged unescapable stress, chronic use of alcohol, chronic use of coffee, and chronic ingestion of simple and refined carbs. Although you have not been totally explicit, it sounds likely that you have indulged and been exposed to all of those with Accuane being the straw which broke the camel's back. You have taken the preliminary steps toward recovery, but unless you take all the steps, you will not recover. Once the mercury is out, one needs to proceed to the SanPharma Protocol - the German isopathics in combination with drainage remedies (made by Pekana) and intense nutritional support. The prognosis for complete recovery is excellent if you eliminate all the provoking agents and follow through to completion of treatment. As to Penicillamine, it is probably not necessary. I am in the habit of using it, and it does work, but like you say, DMSA alone will do the job. When all is said and done your gut should be intact again and you will know how to keep it that way.

RE: Mercury Toxicity / Chronic Gut Wall Infection
Posted by: Jordan
Date: February 7, 2004 5:25 PM

So does this mean the gut wall is the source of my symptoms, and not the mercury itself? Also, I have read a bit about how the liver, kidney, thyroid etc., can be affected. Does the SanPharma and Pekana Remedies help in detoxifying these organs, and basically what does this protocol do? Also, should I start the protocol while still chelating the mercury out or wait until it's out completely? Do you have any recommendations in terms of nutrition while I am going through this? Finally, where can I get the SanPharma and Pekana Remedies?

RE: Mercury Toxicity / Chronic Gut Wall Infection
Posted by: Ron Kennedy, M.D.
Date: February 7, 2004 7:27 PM

You have to find a practitioner who used these remedies. That may be a challenge as they are unknown in mainstream medicine. I have no idea where you live, but you can always come see me in Santa Rosa. I have my own nutritional formula which I designed for people who are going through this protocol. If you want to order that, it is available through the red "Order Supplement" tab above left. Is is called Ultra. For the best results you should not begin the protocol until the mercury (and other metals) are down to reference range as measured by a DMPS Challenge Test. The protocol does two things: it restores your digestive functions by retraining your immune system to eliminate pathogenic organisms so that you can maintain a normal gut flora. The source of symptoms in such a case is two-fold: (1) loss of the ability to digest properly due to dysbiosis and damage to the gut wall itself and (2) interference with normal thyroid (and other hormone - adrenal and sex steroids) effects by heavy metals. Both of these conditions, the digestive dysfunction and the metals slow metabolism and account for the symptoms.

RE: Mercury Toxicity / Chronic Gut Wall Infection
Posted by: Jordan
Date: February 10, 2004 5:29 PM

After I have finished chelating the mercury out of my system, and completed treating the gut wall with the San Pharma and Pekana remedies, in the event that I do not see improvement, could it be that I would need hormone replacement therapy at that point (T3 protocol, Corticosteroids, etc..)? Have my glands been bogged up by my usage of synthroid, T3, prednisone to the point that I may need permanent hormone replacement therapy?

RE: Mercury Toxicity / Chronic Gut Wall Infection
Posted by: Ron Kennedy, M.D.
Date: February 11, 2004 5:23 AM

Everything should come back to the way it would have been had you never been ill once the toxins are out and eubiosis has been reestablished. However, that might mean hormone replacement therapy would be of benefit depending on your age and genetic constitution. Only proper testing would be able to yield that answer.

RE: Mercury Toxicity / Chronic Gut Wall Infection
Posted by: Jordan
Date: February 11, 2004 5:51 AM

I am planning on ordering the "Ultra" product as I agree with you in thinking it would be of help. I should take it however only on those five days when I am not on DMSA though, right? Also, could you please specify which products I need for the gut wall infection from SanPharma and Pekana (i.e.- what are the SanPharma and Pekana remedies?) as my naturopath carries some of their products. Thanks again...

Jordan

RE: Mercury Toxicity / Chronic Gut Wall Infection
Posted by: Ron Kennedy, M.D.
Date: February 11, 2004 12:35 PM

Now we have reached the limit of this format. This is an informational service, not designed to deliver proper treatment. From a medical-legal standpoint, I cannot recommend treatment, and there is a very practical reason for that: not having done a full evaluation, any treatment I could recommend would be generic, probably inaccurate, and most likely a waste of your time and resources. All these things must be done in the proper sequence or they do not work. Steps cannot be skipped. As to DMSA and Ultra, there is very little interference between the two. Most of my patients, at that stage, take both and get the result.



This Thread has been closed

 




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