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24-hr urine test vs saliva test for hormones
Posted by: Jackie
Date: March 28, 2003 1:58 AM

I am 40 year old female with a long history of hypothyroidism and estrogen dominance (and at one time, hypoadreanalism, but no longer). Because of your great advice, I am now in my 4th month treatment for Wilson's Syndrome using the timed released T3. My temp. has gone up, I no longer lose my hair, no longer have cold hands and feet, less fatigued, better memory, etc. However, I have PMS for about 21 days out of the month and no longer have any sex drive. The doc treating me for Wilson's Syndrome had me go off of my natural progesterone cream when I started the treatment for Wilsons. The doc felt my PMS problems would probably go away once on the treatment, but the longer I am off the cream, the worse and longer my PMS gets as the months go by. (For 21 days my stomach swells and my swollen breasts hurt so bad that I can barely wear a bra, etc.) What makes a person estrogen dominate? Also, what testing gives the most accurate results for hormone levels, the 24-hr urine from AAL labs or the saliva test? What hormones would you recommend I test? In addition, your answer to my question on 9/16/02 (as well as your answers to questions from other people) lead me to believe that you treat people with the timed release T3 on a permanent basis. Is this correct? My doc feels that is not the right protocol. However, I have a feeling that I will do better permanently on the timed released T3 than going back on Armour once my Wilson's treatment cycles are done. (unless treatment for Wilsons cures me of hypothyroidism) What do you think?

RE: 24-hr urine test vs saliva test for hormones
Posted by: Ron Kennedy, M.D.
Date: March 28, 2003 3:32 AM

It is good to hear that you are receiving so much benefit from the Wilson's protocol. However, it is important to keep in mind that there are other hormone systems which must operate correctly for good health. Prominent among these are growth hormone and the adrenal steroids which includes the glucocorticoids and the mineralocorticoid (aldosterone) as well as the sex steroids. The term "estrogen dominance" refers to a condition where the toxic effects of estrogen are not countered by progesterone, so the cause is the underproduction of progesterone or overproduction of estrogens. You mention the AAL Labs test - their 24 hour urine collection is the best on the market, far superior to blood tests and light years better than saliva tests. I suggest the test which measures all the hormone systems including E1, E2, and E3 as well as HGH. Three things can underlie poor hormone production and balance: age (which we can do nothing about), stress, poor diet, and toxic conditions, particularly heavy metals and most commonly mercury toxicity. Absent sex drive is most often due to weakness in the testosterone system and/or the growth hormone system. I treat people over 40 with time release T3 exclusively provided the AAL Lab results indicate weakness in the thyroid system and sometimes on a temporary basis even if the results are normal if they are clinically hypothyroid and plan to remove dental amalgams and undergo heavy metal detox (since heavy metals, particularly mercury, can block the action of thyroid hormone at the cell receptor site).

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