Cold Agglutinin Disease
Cold agglutinin disease is an acquired autoimmune hemolytic anemia due to an autoimmune antibody (usually) directed
against an antigen on the surface of red blood cells. These autoantibodies (of the IgM variety) usually will not react with cells
at 98.6° but only at lower temperatures.
Since the blood temperature (even the hands and feet) rarely goes lower than 68° only antibodies active at higher
temperatures than this will produce effects.
In the cooler parts of the body (fingers, nose, ears), the antibodies will cause the red blood cells to stick together briefly. Cell
damage results indirectly from attachment of the protein to the cell wall by complex reactions.
Autoimmune disorders are caused when the body’s immune system, which is meant to defend the body against bacteria,
viruses, and any other foreign product, malfunctions and produces antibodies against healthy tissue, cells and organs.
Most cases of chronic cold agglutinin disease are of undetermined origin. Others occur in association with Waldenström’s
macroglobulinemia, a malignant lymphoproliferative disease in which a monoclonal IgM paraprotein is produced. Acute
post-infectious cold agglutinin disease occurs following mycoplasmal pneumonia or infectious mononucleosis
Conventional treatment involves the use of Prednisone and other corticosteroids. Often patients are unable to tolerate the
toxic side effects of these drugs.
The alternative, nutritional medicine approach is to identify hidden allergies by blood test and avoid those allergens (primarily
foods). Also enzyme potentiated desensitization holds hope for putting the disease in long term remission.
The approach used in homeopathy is to attempt to restore the balance of the system using dilute solutions of natural
substances specific to the disorder.