Chemical Menopause

Chemical Menopause

Dr. Kennedy
Chemical menopause is an “induced menopause,” induced by an unusual event, such as may also occur when the ovaries are damaged by radiation or when the ovaries are surgically removed (by bilateral oophorectomy). Induced menopause, chemical menopause included, is distinct from natural menopause which occurs when the ovaries naturally decrease their production of the sex hormones estrogen and progesterone.

Examples include the GnRH Agonists (synthetic forms of the gonadotropin-releasing hormone). They work by stopping FSH and LH production in the pituitary gland, and thus stopping hormone production in the ovaries. When administered, most women will stop ovulating and menstruating, and go into sudden chemical menopause. These medications include:

  • Lupron (Leuprolide)
  • Zoladex (Goserelin)
  • Synarel (Naferelin acetate)
  • Decapeptyl – (triptoreline)
    Suprefact, Suprecur, and Sepremon (buserelin acetate) (not available in U.S.)

    Also producing chemical menopause are:

  • birth control pills
  • progestins (Provera, Cycrin- Medroxyprogesterone) (Megace – Megestrol Acetate) (Micronor, Norlutin, Aygestin, Norlutate – Norethindrone) (Depo-Provera – depot-medroxyprogesterone acetate or DMPA) and (Ovrette)
    Provera, Cycrin (Medroxyprogesterone) – 20-100 mg daily
    Pharmacological information for Provera
    Megace (Megestrol Acetate) – oral progestin – 10-80 mg daily
    Pharmacological information for Megace

    Micronor, Norlutin, Aygestin, Norlutate (Norethindrone) – oral administration
    Pharmacological information for Micronor

    Depo-Provera (depot-medroxyprogesterone acetate or DMPA) -150 mg by deep intramuscular injection every 3 months
    Pharmacological information for Depo-Provera

  • synthetic testosterones

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