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Doctors are now using Calcium EDTA as a substitute for Magnesium EDTA in IV therapy. This is a 45-60 minute procedure which is also given intravenously. It is convenient for patient in terms of time saved and appeals to the patient pressed for time. It appears to be a full substitute for the three hour magnesium EDTA drip. Unquestionably, it works to relieve angina, that is nothing new. In fact, that is how EDTA was first discovered as a treatment for heart disease. In the early 1950’s, a doctor in Detroit, Norman Clarke, M.D., treating many patients in the automobile industry for lead poisoning, kept hearing "Gee, doc, my chest pain is better." There is no question that calcium EDTA has a calming effect on angina. We once believed this effect to be mediated by calcium removal, but as experience accumulates it is becoming obvious that this is not the mechanism at work. Blood flow and oxygenation definitely are improved with the use of EDTA and what we know now is that the smallest (microscopic) arterial vessels (called "arterioles") open up and provide a physiologic bypass around hard plaque. This effect is probably achieved by the removal of heavy metals from the vascular intima allowing the vessel to relax and expand. It may be that calcium EDTA achieves this effect as well as magnesium EDTA and if so, the convenience in time saved for the patient is a big plus.
Incidentally, since 2000 we do have something to remove hard plaque – Plaquex (intravenous phosphytidal choline). This stuff really works, and I advise my patients with serious vascular disease to alternate it with intravenous EDTA.