“Angiopathy” denotes disease of the blood vessels (arteries, veins, and capillaries). There are two basic types of angiopathy: microangiopathy and macroangiopathy. In microangiopathy, the walls of small blood vessels become so thick and weak that they bleed, leak protein, and slow the flow of blood. For example, diabetics may develop microangiopathy with thickening of capillaries in many areas including the eye. In macroangiopathy, fat and blood clots build up in the large blood vessels, stick to the vessel walls, and block the flow of blood. Three locations of macroangiopathy are coronary artery disease (in the heart), cerebrovascular disease (in the brain), and peripheral vascular disease (affecting, for example, vessels in the legs).