Achlorhydria is the total absence of hydrochloric acid in the digestive juices of the stomach. It can be due to many diverse causes including: pernicious anemia (caused by autoimmune gastritis), other autoimmune conditions – such as autoimmune thyroid disease (Hashimoto’s thyroiditis) and any cause of severe chronic gastritis. Heliobacter pylori is the most common agent that may lead to destruction of parietal cells, the cells that make hydrochloric acid in the stomach, and thus lead to achlorhydria. In addition to treatment of the underlying condition, supplementation with betaine HCL is critically important. This should be done only under a doctor’s supervision.