SAMe (S-adenosyl-L-methionine)

SAMe (S-adenosyl-L-methionine)

Dr. KennedySAMe (pronounced Sammy) is an amino acid based substance produced throughout in the human body. SAMe is perhaps the best antidepressant discovered so far. Most synthetic drugs interfere with normal bodily functions and artificially reduce depression. SAMe boosts the body’s innate ability to create the vital neurotransmitters which make depression history.

SAMe is used in methylation, a vital process in detoxification and in neurotransmitter formation. SAMe’s place in methylation reduces homocysteine (a toxic metabolite) that is proving to be a larger risk factor in heart disease than high cholesterol. SAMe is the body’s base element for the formation of sulfur based compounds like glutathione (one of the body’s main naturally occurring anti- oxidants) and joint restoring compounds like glucosamine and chondroitin sulfates. Both in clinical studies and in practice, SAMe is effective in treating depression, osteoarthritis, fibromyalgia, liver disorders, and migraine headaches.


SAMe enhances the production of brain neurotransmitters as well as phospholipids which give energy to bran metabolism. SAMe also enhances the production of acetyl choline which is an integral part of learning and memory. Serotonin and dopamine are  enhanced by SAMe as it facilitates their binding to the proper receptor sites in the brain. Because of SAMe’s detoxification power, long term use should improve central nervous system health. SAMe has also been shown to have far fewer side effects than the commonly employed antidepressants. SAMe works fast, taking from a few days to two weeks for most cases of depression.


SAMe has been shown to prevent liver cancer in animals exposed to liver toxic chemicals, and thus may be useful for people who are exposed to toxins of various kinds including alcohol, those on chemotherapy or other liver draining toxic drug therapies.

The Liver

SAMe is the liver’s major methyl donor and with glutathione is an integral part of the liver’s detoxification process. SAMe is also helps in the processing of fats and oils. SAMe is, according to most sources, helpful in the following liver disorders: Gilbert’s Syndrome, gallstones, cholestasis, sluggish liver, hepatitis, jaundice, cirrhosis, cancer, alcohol and drug abuse, fatigue, accidental ingestion of liver toxins, and general liver failure.


Through its improvement of the body’s detoxification mechanisms and its enhancement of the natural anti-pain chemicals the body normally produces, SAMe has proven remarkably effective in treating fibromyalgia.


Because of its transulfation activity, SAMe provides the basic biochemical sulfur compounds (glucosamine and chondroitin sulfate) which the body uses to form new collagen, especially cartilaginous tissues.

Migraine Headaches

SAMe is also beneficial in the treatment of migraine headaches. It takes more time for effecting relief from migraines, but nevertheless, SAMe is free of the side effects produced by pharmaceuticals.


Through its interaction and influence over the brain’s neurotransmitters such as dopamine and serotonin, SAMe may also alleviate insomnia. Serotonin and dopamine have long been at the top of the list of neurotransmitters responsible for sleeping, dreaming, etc. SAMe’s influence over these substances has been reported to help relieve insomnia in many cases.

Comments are closed.