SACE Test (Serum Angiotensin Converting Enzyme) (ACE Test)
SACE is ordered when there are signs or symptoms such as granulomas, chronic cough or shortness of breath, red watery eyes, and/or joint pain that may be due to sarcoidosis or to another disorder. This is especially true between 20 and 40 years of age, when sarcoidosis is most frequently seen. Other tests such as an AFB culture or sputum culture (tests that can detect mycobacterial and fungal infections) may be ordered to differentiate between sarcoidosis and another granulomatous condition. If diagnosed with sarcoidosis and the initial ACE levels are elevated, SACE testing at regular intervals monitor the progress of the disease and the efficacy of treatment over time. ACE will be elevated in 50% to 80% of patients with active sarcoidosis. Concentrations of ACE tend to rise and fall with disease activity. This test has no single number that identifies an abnormal result. The lab report should include a range of numbers (reference range) that identifies what is expected based on age, sex, and the method used in that laboratory.