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The Hunger Project Bolen Report
Ohm Society
Untitled
Testosterone Therapy Print E-mail
by Ron Kennedy, M.D., Santa Rosa, CA

Dr. Kennedy Anaerobic Metabolism
Aerobic Metabolism
Cortisol and the Catecholamines
The Great Cholesterol Hoax
The Great Fat Hoax
Adult Onset Diabetes
Fibrinolytic Activity of TNAS
Postsurgical Use of TNAS
Dosage
Side-effects
Considerations
Prophylactic Use
Male Birth Control
Other Diseases of Anaerobic Metabolism
Forms

To understand the value of the use of testosterone in modern medicine, it is necessary to expand our thinking. Testosterone is not simply "the male sex hormone." It is perhaps even unfortunate that it was first discovered in animal testes and thus named "testosterone," implying that it comes only from the testes and thus associating it exclusively with sexual function. Testosterone is best termed The Natural Anabolic Steroid, or TNAS.

The biochemical name of TNAS is a jaw-breaker, and I will write it only once: cyclo-pentano-perhydro-phenanthrene. The hyphens are my addition to this mouthful and help us pronounce this long string of letters. No wonder they named it something else!

The interaction between TNAS and the cell is to increase protein production. TNAS commands the DNA structure of each cell to increase production of RNA. RNA, in turn, migrates from the nucleus into the main body (cytoplasm) of the cell where it increases protein synthesis. Thus, TNAS increases lean body weight at the expense of fatty tissue. Food that would be stored as fat is stored as muscle.

The Natural Anabolic Steroid, or TNAS, should not be confused with synthetic anabolic steroids, which have given such a black eye to steroid therapy. While it is true that synthetic anabolic steroids do increase muscle mass, especially when combined with exercise, they also have a host of potential harmful side effects, especially to the heart. The use of synthetic anabolic steroids by athletes, with associated deaths, has put a large barrier in the public consciousness to the legitimate use of TNAS in medicine. TNAS does not have the life threatening side effects of the synthetic anabolic steroids, because it is a natural hormone made in nature's lab. Therein is the problem for capitalistic pharmaceuticals: no big profits are realizable from a substance from a natural, therefore nonpatentable, source. From the patient's standpoint, however, TNAS is a God-send: a powerful natural element with a large safety factor.

TNAS is made in women as well as in men. The major site of production is the adrenal gland. Castration does not end a man's TNAS production, and women produce sufficient quantities of TNAS. In women, TNAS and estrogens work together to maintain health and positive nitrogen balance (the production of at least as much muscle tissue as is lost each day). Therefore, TNAS is necessary for the maintenance of health in women, as well as men.

Anaerobic Metabolism

To understand the value of TNAS, we must understand the principles of aerobic and anaerobic metabolism. When life first began on the earth, it used what was available for energy. That substance, which was most available in the early atmosphere, was carbon dioxide, or CO2. This CO2 was in plentiful supply, and every time another volcano erupted it spewed millions of tons more of CO2 into the atmosphere.

In these early organisms, CO2 was burned for energy, and the left-over waste product was oxygen in its most stable form, O2. After hundreds of millions of years of this activity — single cell organisms burning CO2 and producing O2 — an atmospheric pollution crisis was created. The atmosphere was so full of O2, these anaerobic organisms were dying in their own waste product.

However, life is creative, and soon the solution was at hand. These early bacteria split into two groups. Some of them remained anaerobic, burning CO2 for energy, and another group developed the ability to burn O2 for fuel, producing CO2 as a waste product! Plants also are the descendants of these early anaerobic organisms, and therefore they also use CO2 for energy and leave O2 as a waste product. This fact makes life possible for aerobic organisms like you and me. Without plants, we would run out of O2 in short order.

So life is divided into aerobic and anaerobic organisms. The multicellular anaerobic creatures are called "plants." By banding together as many cells and by developing protective skin-like structures, they are able to protect themselves from atmospheric O2. Anaerobic bacteria, on the other hand, are obliged to live in cracks and crevices where they can hide from the toxicity of O2. They live best where the gaseous form of oxygen is not present.

Bacteria which cause human disease all are anaerobic, while the aerobic bacteria (which live in the intestine) have become useful in digestion, and some actually manufacture vitamins for us. One form of life intermediate between plants and bacteria has developed, known as "fungi," which are anaerobic and quite a nuisance to human health, predisposing to fungus infections of the lungs, toes, nails and the more generalized Yeast Syndrome.

Aerobic Metabolism

We are, as all multicellular animal life is, primarily aerobic in our metabolism. We prefer oxygen to help us burn (oxidize) our food into usable from. However, there is a characteristic of nature important to remember: if nature knows how to do something and this knowledge becomes obsolete, it is placed in storage rather than thrown away. The cells of your body know how to conduct anaerobic metabolism; i.e., they can, to a limited degree, burn food without the benefit of O2.

Ordinarily, aerobic metabolism predominates, because it is so much more efficient. However, when conditions make aerobic metabolism difficult, the cells of your body can shift toward anaerobic metabolism.

It is interesting to note that cancer cells use sixty percent anaerobic metabolism. Anaerobic conditions may be a significant risk factor for cancer. The fact is, in normal cells both types of metabolism are going on at all times, but the experience of vital, normal health requires that aerobic metabolism predominate. That is where TNAS comes in.

TNAS is the primary balancing hormone which maintains aerobic metabolism as the major source of energy for the body. When TNAS levels fall, anaerobic metabolism is used in proportion to the fallen level of TNAS.

(By the way, you can know that your body has shifted toward anaerobic metabolism if you crave sweets. Sugar is the fuel source of anaerobic metabolism.)

TNAS begins to be found in increased levels around age eight to ten and reaches a maximum level at around age eighteen. After that, it falls off progressively until at age sixty or seventy it is found at very low levels. At any age, the production of TNAS can be encouraged by aerobic exercise. Somehow, the body knows that increased levels of O2 need increased levels of TNAS for proper utilization.

This is one of the major benefit of an exercise program: increased levels of TNAS. When we doctors prescribe exercise we are actually prescribing a means of producing an increased level of TNAS. This, in turn, improves carbohydrate metabolism and normalizes lipase — thus helping to shift fat to protein. Exercise lowers cholesterol in a natural way by shifting metabolism to the aerobic end of the spectrum, using acetyl-CoA in the Krebs Cycle more and using it to construct excess cholesterol less.

The diseases of aging are, at least theoretically, traceable to the decreased supply, and the inefficient usage, of oxygen. As age overtakes us, the heart/lung/vascular system loses the ability to deliver as much oxygen to the body as it once did, and the body loses the ability to use what oxygen it receives as well as before. These abilities begin to decline at age thirteen! It has been demonstrated that even highly trained athletes cannot duplicate for very long the activity level of ordinary children at play.

If it is true that the diseases associated with aging are due to a decreased supply and inefficient utilization of oxygen, it should be possible to alleviate these diseases at their root by any means which increase the supply, and/or the utilization of oxygen. Thus, where standard medicine tries to artificially suppress symptoms with synthetic medications, in progressive medicine we do chelation therapy, hydrogen peroxide therapy, recommend vitamins, exercise, dietary changes and other measures to combat diseases at their root cause by increasing oxygen delivery and utilization.

The hormone system plays a powerful role in oxygen use. For example, thyroid hormone regulates the rate at which oxygen is used in oxidation. Insulin regulates the entry of glucose (the major source of fuel for aerobic metabolism) into cells. And TNAS serves to shift metabolism away from anaerobic toward aerobic. It powers up the Krebs Cycle (also known as the "citric acid cycle"), the basic metabolic route the body uses to produce energy through oxidation.

Let us take the example of heart disease. Of the average 100 people in our society, forty of these will die from heart disease. Thirty-two of these forty will die after age 65 and eight will die before age 65. Of these eight, four will have hereditary problems leading to heart disease. Heart disease can be expected in these four; however, that leaves the other four people with no identifiable risk factors (not age and not family history) who will die of heart disease before age 65. These people simply develop anaerobic metabolism at an early age of sufficient degree to cause damage to heart muscle.

The common medical explanation for a heart attack is that a coronary artery is partially blocked by atherosclerotic lesions. Turbulence in blood flow, produced by this partial blockage, leads to thrombosis (clotting) and complete blockage of the coronary artery, resulting in loss of blood supply to the heart muscle supplied by that artery. Thus, the muscle is said to die due to loss of blood supply.

That explanation held up until someone demonstrated that approximately half of heart attacks happen before coronary thrombosis and not after. In some cases heart attack has happened, and there is no blood clot present. This brings up the possibility that the thrombosis which happens inside the coronary vessels and death of heart muscle have a common cause and are not causally related to each other.

It is well-known that TNAS has a powerful "fibrinolytic" effect. That means that it tends to prevent blood clots, and when they happen it breaks them up. A lowered level of TNAS, therefore, predisposes to blood clots. Therefore, the blood clot which forms in the coronary artery and the death of surrounding heart muscle may both be caused by lowered levels of TNAS.

If thrombosis often has a common cause with "heart attack" (death of heart muscle fibers), rather than being the cause of heart attack, what is the true cause? When that question came up, someone postulated that coronary spasm (the coronary artery squeezing itself shut) may cause heart attack in the absence of thrombosis, even in the absence of any vessel disease. In other words, the blood vessel chokes the heart muscle to death and then relaxes leaving no evidence of what happened.

Radiographic films have been made of this process happening while the heart circulation is being examined with dyes and x-ray. So we know that it can happen while the heart circulation is being examined with dyes and x-ray. We do not know, however, that it can happen when the heart circulation is not being examined with dyes and x-ray. Because of this, I suggest you decline to have your heart circulation examined with dyes and x-ray ("angiograms" they are called).

The other possibility is that the heart attack originates in the heart muscle itself due to a shift to anaerobic metabolism. This makes some theoretical sense in that the heart is the only muscle in the body which is not allowed to take a break and rest. It must contract fifty to eighty times per minute to sustain life. If it goes on a break, you die. This kind of demand is not made on any other muscle. If there is a shift to anaerobic metabolism in the heart muscle, it may just work itself to death in short order, even with a sufficient blood supply. Remember aerobic metabolism depends not only on oxygen supply but oxygen utilization as well.

All muscles store energy in the form of adenosine triphosphate (ATP). ATP is made from adenosine monophosphate (AMP) by the addition of two phosphate groups, a process called "phosphorylation." In anaerobic metabolism, phosphorylation proceeds at a slower pace, resulting in a bottleneck effect at the level of two phosphate groups (adenosine diphosphate or ADP). Lowering the ATP level to less than fifty percent of normal results in irreversible tissue death. In some heart attacks, this is what happens. The muscle simply dies in a region of the heart, and this causes clotting in the coronary arteries. What was once considered the cause of a heart attack is sometimes the effect. The cart goes before the horse.

The major function of TNAS is to maintain aerobic metabolism. As we age, we not only receive a decreasing supply of TNAS, but also cells become resistant to the effects of all hormones. Thus, for TNAS to produce the same result in a sixty year old person as it does in a twenty year old person, there must be a higher level of TNAS in the older person.

The cause of heart disease is complex, but it is clear that a shift from aerobic to anaerobic metabolism plays an important part.

Treatment of Heart Disease with TNAS

Thus, the theoretical basis for treatment of heart disease with TNAS is solid and, although in the United States this treatment is not in vogue, probably due to blind prejudice against the word "testosterone," the use of TNAS for heart disease in Denmark is decades old. Dr. Jens Moeller has used TNAS in the treatment of angina in Copenhagen with great success for over forty years.

Dr. Moeller has discovered that tissue resistance to TNAS in the older person sometimes requires the administration of several times the usual dose of TNAS for symptom relief of the pain of angina. Dr. Moeller is the president of the European Organization for the Control of Circulatory Disease. He is an original thinker and a courageous physician who points out some very interesting things in his ironically misnamed 1987 compendium "Cholesterol." This should be required reading for any physician who treats vascular disease.

Cortisol and the Catecholamines

In normal metabolism there is a balance between protein synthesis and breakdown. TNAS encourages protein synthesis, and an adrenal hormone named "cortisol" (hydrocortisone) acts antagonistically and encourages the breakdown of protein. The breakdown of protein also is encouraged through chronic tension and anxiety (as many underweight worriers can tell you) through the production of the catecholamines — adrenalin and noradrenalin (also called "epinephrine" and "norepinephrine"). Stress raises both cortisol and catecholamine levels and, if stress becomes constant, the hormonal balance between TNAS, cortisol and the catecholamine is upset. Indeed, this balance is upset by the aging process itself, by the decreased production of TNAS and the increased production of the catecholamines, which occurs with age.

This is the root cause of stress-induced heart attacks: the shift toward anaerobic metabolism caused by the domination of the effects of cortisol and the catecholamines over TNAS. When this condition becomes chronic, angina may begin, because the heart muscle is unable to utilize oxygen in the usual efficient manner. In experimental animals, administration of excess cortisol alone has been shown to produce death of heart muscle. Excess catecholamines can cause the heart to go into ventricular fibrillation, which results in death rather quickly. This can happen when there is a very upsetting event — a person is literally scared to death.

While most people are not subjected to catastrophic levels of cortisol or the catecholamines, the aging heart is subject to a hormone imbalance which is harmful, even in the absence of vascular disease. One solution is to shift metabolism back toward the aerobic condition through the administration of TNAS, thus restoring the balance which has been lost.

The Great Cholesterol Hoax

Cholesterol, despite the vilification of this substance by the medical establishment, is simply an innocent bystander in the biochemical drama of vascular disease. Cholesterol is made constantly in the liver and is essential for life itself. It is the precursor for the male and female sex hormones and the adrenal cortical hormones as well. The body uses cholesterol to make these hormones.

When metabolism becomes relatively anaerobic, the enzyme systems which alter cholesterol to make these hormones are unable to function normally. This results in the accumulation of cholesterol. Thus, an increased cholesterol level is a signal that metabolism has shifted toward the anaerobic and alerts us that we should do what is necessary to deliver more oxygen to the tissues and also to condition the tissues to use that oxygen more efficiently.

Cholesterol is made in the liver from acetyl-CoA, which also is used by aerobic metabolism in the Krebs Cycle. When the Krebs Cycle is not functioning well, acetyl-CoA builds up, and the production of cholesterol is accelerated, because the raw building block material, acetyl-CoA, is in abnormal excess due to the fact that it is not being used at the normal rate by the Krebs Cycle.

Therefore, cholesterol level is only a marker and not the cause of the problem itself. Giving the person a drug to inhibit the production of cholesterol, while yielding great profits for the pharmaceutical manufacturers of these substances, does nothing to lower overall death rate. The studies which show evidence that lowering cholesterol in this manner lowers the incidence of heart disease or death from heart attack were sponsored by the drug companies which make the drugs. This introduces investigator bias. Also, other studies demonstrate increased death rate due to automobile accident and suicide in people taking cholesterol lowering drugs. Draw your own conclusions.

The mesmerization of the public with the idea that cholesterol is somehow the cause of vascular disease has been called "The Great Cholesterol Hoax" by some writers. It is a marketing creation, which makes enormous wealth for the food and pharmaceutical industries. It also gives doctors something to do to feel useful: help you drive your cholesterol level down by artificial means.

If one takes those actions which promote aerobic metabolism it is true that the cholesterol level will drop naturally, with no medications to force it down and no dietary changes. These actions include regular aerobic exercise and a revitalization of the hormone system. An important part of this revitalization is the administration of the appropriate amount of TNAS. I am not saying that a low-fat diet, vitamins, etc., are of no value. I do say, however, that compared to aerobic exercise and hormone balance, they are running only a close third and fourth in importance. Ideally, one would make all these changes sooner rather than later and at the very latest when the first signs of vascular/metabolic dysfunction appear.

The Great Fat Hoax

While it is true that the reduced dietary consumption of fat is proper for maximum health, it is not the fat itself which is the problem. Toxic materials, such as herbicides, pesticides and preservatives are stored in concentrated form in animal fat. If you eat this animal fat, you eat these toxins in concentrated form, and most of it ends up stored in the fat of your body. From there the name of the game is "Slow Poison." If you can obtain organically produced meat, you could consider it good food, if eaten in a balanced way with the other food groups. Otherwise, adopt a low- or no-animal-fat diet.

To summarize, TNAS favorably influences the enzymes which power up the Krebs Cycle, and it thus powers up aerobic metabolism, making anaerobic metabolism less necessary and less present. The administration of TNAS lowers cholesterol in the absence of any other medical or lifestyle changes, demonstrating that a shift back to aerobic metabolism has occurred. The dominating influence of cortisol and the catecholamines from aging and stress is reversed, and the probability of a catastrophic cardiovascular accident is greatly decreased.

This is the obviously sensible route to take when dealing with "vascular" disease, be it of the heart, the brain, the kidneys or the extremities. Replacement of vessels with plastic tubes should be absolutely abhorrent to anyone with a medical degree or, indeed, to anyone with knowledge of the behavior of living tissues. Blood vessels are made of living cells. They are not made of plastic and not made of a plastic-like substance. They derive from the same tissues in the embryo which give rise to the red blood cells. Therefore, they are friendly to red blood cells and can allow the passage of these cells without harm. The same cannot be said of plastic substitutes for blood vessels.

The surgical replacement of an artery with a vein is a little less insult to common sense, however not much less. Arteries are designed to withstand many times the pressure for which a vein is designed. Veins in the natural ungrafted state are supplied with blood through tiny arterioles, which feed capillary systems within the vein walls themselves. When a vein is cut from the leg to be grafted into the heart, it is ripped away from its blood supply. This blood supply cannot be replaced, and the vein must therefore derive what little oxygen it can from the blood which passes through it. Although this seems like it should work, it does not. Therefore, a vein will eventually (usually sooner rather than later) develop anaerobic changes and clog when grafted into the arterial system.

In short, surgical intervention in the cardiovascular system is almost never justified when the alternatives are given proper consideration. Chelation therapy, hydrogen peroxide therapy, and hormone therapy along with lifestyle changes yield better and longer-lasting results for a fraction of the cost of surgery and at almost no risk compared to the extreme risk involved in surgery. Even the diagnostic procedures leading up to surgery carry an unacceptable risk when compared to the alternatives.

Adult Onset Diabetes

The aches and pains of growing old are due to anaerobic metabolism. If anaerobic metabolism predominates in the upper back and shoulders there will be intermittent or constant aching in that area. This usually is conceived of as tension, but when anaerobic metabolism is converted back to aerobic metabolism by TNAS, this pain promptly disappears.

The pancreas is made up of two populations of cells. The cells of the Isles of Langerhans are of two types: beta cells (which produce insulin) and the alpha cells (which produce glucagon, a hormone which balances insulin). The Isles of Langerhans (named after the guy who first described them) makes up an endocrine gland which is embedded in a second population of cells. This second population of cells constitutes an exocrine gland, secreting its products not into the blood stream but into the gut. This secretion contains enzymes to digest food.

When anaerobic metabolism strikes the pancreas, the result is poor digestion and/or adult onset diabetes. It is typical for a person to both have diabetes and cardiovascular disease, because the root cause is the same: anaerobic metabolism. This is not the case with juvenile onset diabetes, and in this disease TNAS is not a good treatment. It is a mistake to attack adult-onset diabetes, or any of the diseases of anaerobic metabolism as if they were isolated diseases. The control of blood sugar is a nice goal but if the patient dies of a heart attack in the interim, it is not much comfort to the family that he died with a correct blood sugar. Administration of TNAS, along with correct balancing of protein and carbohydrate intake at 7:10 on a caloric basis, normalizes the glucose tolerance test in adult-onset diabetes after only a few weeks of treatment.

The administration of oral hypoglycemic agents may have the same effects but ignores the root cause of adult-onset diabetes, allowing cardiovascular disease to progress unimpeded. Diabetes should always alert the physician to the presence of CVD, even if there are no symptoms yet present. Adult-onset diabetes should be considered a signal of cardiovascular disease and treated as such. To do less is to ignore the onrushing train while dodging the bicycle crossing the tracks.

Fibrinolytic Activity of TNAS

A major consideration in managing heart disease is the prevention of thrombosis, which can cause the occlusion of coronary arteries already compromised by atherosclerosis. When the possibility of thrombosis is a threat to life, doctors often prescribe "blood thinners" to prevent thrombosis. Again, the root cause of the problem is ignored. When cardiovascular disease is properly treated with TNAS, the patient also is protected from thrombosis by the powerful "fibrinolytic" (clot-breaking) activity of TNAS. This makes the administration of synthetic drugs, such as coumadin, unjustifiable. Many patients have died from the treatment where coumadin is concerned. An overdose of coumadin can occur quite accidentally and, if it does, the patient cannot form clots when needed. Therefore, spontaneous internal bleeding becomes a threat to life.

Once again, when the patient dies of spontaneous internal bleeding or from the inability to form a clot and heal a severe cut, it is little comfort to the family to know that he was well-protected from heart attack when he died.

Postsurgical Use of TNAS

When surgery is necessary, it is important for the surgeon to know that the stress of surgery drives up cortisol and catecholamine levels and drives the level of TNAS down. Thus, the patient is a sitting duck for a leg vein thrombosis followed by the breaking loose of this thrombosis in the large veins of the legs and abdomen, with the subsequent migration of this thrombosis to the heart — where death can quickly ensue. When a thrombosis breakes loose it is called an "embolus" and may quickly lead to death. The postoperative administration of TNAS not only speeds healing, but also protects the patient from the hazard of thrombosis and subsequent embolism.

Dosage

The correct dose of TNAS for a man with refractory angina is 250 mg testosterone enanthate three times in the first few weeks until pain is controlled. After that the patient should be titrated to the smallest effective dose, which might be between 200-1000 mg. per week. Women are more easily managed and require only 100 mg. per week in the first few weeks. Once the effective dose is determined, the switch can be made to the oral form.

Side-effects

The lower dose in a woman usually avoids the masculinizing effects of TNAS (hirsutism, lowered voice), but not always. Some men experience an increase in aggressive feelings. Both men and women should be warned in advance of these possibilities and asked to sign a release acknowledging having received this information.

Once TNAS therapy is begun, the aerobic pathways, through which hormones are created from cholesterol, are empowered, and the result is an increase in endogenous hormones, including TNAS itself.

Considerations

It is interesting to consider why TNAS therapy has not caught hold in American medicine. Usually doctors favor treatments which give dramatic results, because this enhances the image of healer. However, in the case of TNAS, there are powerful reasons for it to be ignored or attacked as a quack therapy. First of all, we live in a society which tries to suppress sexuality. Because the name "testosterone" reminds of sex, it is natural that there should be an unconscious reaction against this valuable hormone. For this reason I have renamed it "The Natural Anabolic Hormone." Second, TNAS is a natural part of the makeup of all humans. Therefore, it cannot be patented, so the old story — no big profits, no advertisement, no drug reps in the doctor's office touting the effectiveness of "testosterone" for the diseases of aging. Then there is the association with the synthetic anabolic steroids, which have caused so much damage to athletes. Even though TNAS is the natural anabolic steroid and has never caused damage to anyone, the words "anabolic steroid" bring up the association with synthetic steroids.

Prophylactic Use of TNAS?

Japanese doctors use TNAS as soon as the biochemical markers of anaerobic metabolism are noted (primarily elevated cholesterol). Should we also do that? It is not likely that the medical establishment will be endorsing this treatment anytime soon.

A prominent doctor I recently talked with at a medical meeting made this statement about vitamin E: "I can't recommend it to my patients as something to prevent heart attack, but you better believe I take my vitamin E every day!" I expect many doctors would say the same about TNAS.

If I believe something to be valuable, and safe as well, I recommend it. I believe TNAS is an important part of preventing the diseases associated with the dominance of anaerobic metabolism.

Other Diseases of Anaerobic Metabolism

The diseases which usually are thought of as due to poor circulation are the diseases which are most benefited by TNAS. They are not only heart disease with angina, but gangrene and impending gangrene of the lower extremities. The ideal treatment of gangrene is Chelox Therapy (a combination of chelation therapy and hydrogen peroxide therapy) in conjunction with TNAS therapy.

The prevention or treatment of stroke with TNAS is not so clearly indicated. It is not clear that a stroke is an area of the brain which has gone anaerobic, although this may be the case. No one has clinical experience in preventing strokes with TNAS, because strokes come so often without warning. Sometimes they are not even preceded by transient ischemic attacks (sudden dizziness, clumsiness and sometimes difficulty speaking). However, I can tell you if I had TIAs (transient ischemic attacks) I would be on TNAS without delay along with DMSO therapy.

Male Birth Control

TNAS is used for male birth control in China on a wide scale. Physiologic doses of TNAS on a regular basis cause a virtual disappearance of sperm from the male ejaculate. Given the serious problems of female birth control pills, it would be a great service to the women of our country for this use of TNAS to be made known. Of course, the drug companies are working on a "male birth control pill" which, if it is ever developed, will be some alteration of the natural TNAS molecule. It will therefore be patentable and highly profitable. It will be super-expensive, and it will not work better than TNAS. It probably will not have the health-giving properties of TNAS either.

Forms of TNAS

TNAS comes as an injectable in an oil base, which disperses over a ten to fourteen day period. This is the best form for most people, providing a constant level of TNAS in the body. Occasionally a person becomes aggressively argumentative in the first day or two after an injection, particularly toward the spouse, if there is one. The patient should be warned of this possibility. For this sensitive individual, a smaller, more frequent dose is advisable. Each person is different, and treatment should be individualized.

The oral, methylated form of TNAS (methyl testosterone) has been taken off the market in Europe because of its proven association with liver cancer. However, it is still available in the U.S., and is the only form of testosterone known to most allopathic doctors. While the FDA want to regulate the sale of vitamins, they continue to allow a substance on the maket which is proven to increase the incidence of cancer. Meanwhile, many doctors are unaware that oral, orthomolecular, human testosterone is available through compounding pharmacies. In fact, there are several generations of doctors who do not even know what a compounding pharmacy is.

You can be sure drug companies would like the natural form of TNAS (USP Testosterone) removed from the market, and are looking for a justification for their colleagues at the FDA. It will be difficult, however, for the FDA to argue that a hormone made in the human body is dangerous when given in physiologic doses in the natural form.

By the way, as with all the other natural hormones of which I write in this website, you cannot just bop down to your family doctor, get a prescription, and go pick it up at your favorite pharmacy. You cannot, unless your doctor practices nutritional medicine and your pharmacist is a compounding pharmacist. The standardized doctors generally do not even know orthomolecular human hormones are available, so snowed are they by the pharmaceutical companies; and the average pharmacist cannot even remember what they taught in pharmacy school about compounding. The only skills a pharmacist needs today is the ability to count colored pills.

To find the compounding pharmacist closest to you, contact:

Professionals and Patients for Customized Care
10925 Kinghurst #508
Houston, TX 77099(800)435-1412

Sources

  • Kumada T, Abiko Y Enhancement of fibrinolytic, and thrombolytic potential in the rat by treatment with an anabolic steroid, furazabol. Thrombos. Haemostas. (Stuttg.). 36,1976
  • Moeller J Cholesterol Springer-Verlag Berlin Heidelberg New York London Paris Tokyo ISBN 0-387-17097-9 (U.S.) 1987
  • Allison SP, Prowse K, Chamberlain MJ Failure of insulin response to glucose load during operation and after myocardial infarct. Lancet I.292:478-481;1967
  • Allison SP, Tomlin PJ, Chamberlain MJ Some effects of anaesthesia and surgery on carbohydrate and fat metabolism. Br J Anaesth 41:588-593;1969
  • Breier C, Muelberger V, Drexel H, Herold M, Lisch H-J, Knapp E, Braunsteiner H Essential role of post-heparin lipoprotein lipase activity and of plasma testosterone in coronary artery disease. Lancet June 1:1242-1244;1985
  • Carruthers M Danish experiences in the treatment of advanced circulatory disease with anabolic steroids. Bullitin EOCCD 6;1980
  • Ehrlich JC, Shinohara Y Low incidence of coronary thrombosis in myocardial infarction. Archives of Pathology 78:432-444;1964
  • Fuller JH, Shiply MJ, Rose G, Jarrett RJ, Keen H Coronary heart disease risk and impaired glucose tolerance. Lancet I:1973-1976;1980
  • Gaardner A, Jonsen J, Laland S, Hellem A, Owren PA Adenosine diphosphate in red cells as a factor in the adhesiveness in human blood platlets. Nature (London) 192:531-532;1961
  • Moeller J The concentration of cholesterol and testosterone in the blood of male patients with circulatory diseases. Bullitin EOCCD 1:1-4;1977
  • Tweedle D, Walton C, Johnston IDA The effect of an anabolic steroid on post-operative nitrogen balance. Br J Clin Pract 27/4:130-132;1973


The information in this article is not meant to be medical advice.�Treatment for a medical condition should come at the recommendation of your personal physician.

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