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The Hunger Project Bolen Report
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Hairy Cell Leukemia Print E-mail

Dr. Kennedy A form of chronic leukemia in which malignant B-lymphocytes (a type of white blood cell) are seen in the bone marrow, spleen, and peripheral blood and when viewed under the microscope, these cells appear to be covered with tiny hair-like projections. Hairy cell leukemia represents 2% of all leukemia. The characteristic features of the disease include marked enlargement of the spleen (splenomegaly), low blood cell counts (pancytopenia), a relatively small number of circulating tumor cells with a hairy appearance, and infiltration of the spleen, liver, and bone marrow by the leukemic hairy cells. Splenectomy (surgical removal of the spleen) provides palliation (some help but not a cure). Treatment is usually with drugs, principally interferon alfa and purine analogues such as cladribine and pentostatin. For resistant cases, a promising immunotoxin has been developed that targets CD22, a molecule expressed exclusively on the surface of B-cells, including virtually all hairy cells.



The information in this article is not meant to be medical advice.�Treatment for a medical condition should come at the recommendation of your personal physician.

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