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Goodpasture Syndrome (Anti-glomerular Basement Membrane Antibody Disease) Print E-mail

Dr. Kennedy An autoimmune disease characterized by a combination of lung and kidney disease - specifically, pulmonary hemorrhage (bleeding in the lungs) and glomerulonephritis (inflammation of the glomerulus) - due to severe inflammation in the basement membranes of the alveolus of the lung and the glomerulus in the kidney with the formation of antibodies to components of the basement membrane at both sites. Symptoms include cough with bloody sputum, bloody urine, decreased urine output, fatigue (weakness) and weight loss. Hypertension and swelling (edema) are also common findings on physical examination. The syndrome is named for the pioneering American pathologist Ernest William Goodpasture (1886 - 1960) who discovered it during the influenza pandemic of 1918.The syndrome has also been named anti-glomerular basement membrane antibody disease.

The information in this article is not meant to be medical advice.�Treatment for a medical condition should come at the recommendation of your personal physician.

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