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Factor V Leiden Print E-mail

Dr. Kennedy Factor V Leiden is a genetic disorder of blood coagulation that carries an increased risk of venous thromboembolism, the formation of clots in veins that may break loose and travel through the bloodstream to the lungs or brain. On the clotting level, factor V Leiden is inactivated about 10 times slower than normal factor V and persists longer in the circulation, resulting in increased generation of thrombin and a hypercoagulable state. Factor V Leiden is the most common inherited disorder of blood clotting in the US, affecting 5% of Caucasians and 1.2% of the Afro-Americans. Individuals heterozygous for the factor V Leiden mutation (with one copy of it) have a slightly increased risk for venous thrombosis. Homozygous individuals (with two copies of the mutation) have a much greater risk of venous thrombosis. The diagnosis of factor V Leiden thrombophilia is made by a coagulation test or DNA analysis of the factor V gene. Effective therapy is available and may involve heparin, warfarin and low-molecular-weight heparins. Anyone who develops deep vein thrombosis should be tested for factor V. Normal factor V is also called proaccelerin.

The information in this article is not meant to be medical advice.�Treatment for a medical condition should come at the recommendation of your personal physician.

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