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Cox-1 (Cyclooxygenase-1), Cox-1 Inhibitor Print E-mail

Dr. Kennedy Cox-1 (Cyclooxygenase-1) is a protein that acts as an enzyme to speed up the production of certain chemical messengers, called prostaglandins, within the stomach. The prostaglandins work within certain cells that are responsible for inflammation and other functions. For example, they promote the production of the natural mucus lining that protects the inner stomach. Cox-1 is normally present in a variety of areas of the body, including not only the stomach but any other site of inflammation.

A Cox-1 inhibitor is an agent that inhibits the action of the enzyme cox-1 (cyclooxygenase-1). The common anti-inflammatory drugs such as aspirin, ibuprofen, and naproxen block the action of both cox-1 and cox-2. Cox-1 inhibitors can reduce inflammation, but they may also decrease the natural protective mucus lining of the stomach. Therefore, these medications can cause stomach upset, intestinal bleeding, and ulcers. In some cases, using a buffered form of a cox-1 inhibitor can e reduce these adverse effects.



The information in this article is not meant to be medical advice.�Treatment for a medical condition should come at the recommendation of your personal physician.

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