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The Hunger Project Bolen Report
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Constitutional Thrombopathy Print E-mail

Dr. Kennedy Constituitonal Thrombopathy (aka Von Willebrand disease) is an inherited bleeding disorder in which a clotting protein called von Willebrand factor is deficient or defective. Von Willebrand factor is made by cells lining the wall of blood vessels. When vessels are damaged, platelets normally clump at the site of the injury. Von Willebrand factor acts as glue to help the platelets clump. Von Willebrand factor is also a carrier of clotting factor VIII, another protein that helps the blood to clot. Von Willebrand disease is the most common inherited bleeding disorder. It occurs in about 1 in every 100 to 1,000 people. There are three major types of von Willebrand disease: Type 1 -- the mildest and most common form of the disease. There is a low level of von Willebrand factor. Levels of factor VIII may also be lower than normal. Type 2 -- a mild-to-moderate form of the disease. Von Willebrand factor does not work as it should. Type 2 is divided into types 2A, 2B, and 2C. Type 3: -- the most severe form of the disease and very rare. Von Willebrand factor is absent and factor VIII is low. All three types of von Willebrand disease affect both males and females.



The information in this article is not meant to be medical advice.�Treatment for a medical condition should come at the recommendation of your personal physician.

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