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Citrulline Antibody Print E-mail

Dr. Kennedy Citrulline antibody (an immune protein) is directed against a circular peptide (a ring of amino acids) containing an unusual ("non-standard") amino acid called citrulline that is not normally present in peptides or proteins. Citrulline is formed by the body as an intermediary in the conversion of the amino acid orthithine to arginine. (Arginine is converted to nitric oxide, the "cleansing agent" of the vascular endothelium.) The citrulline antibody provides the basis for a test of importance in rheumatoid arthritis. The citrulline antibody appears early in the course of rheumatoid arthritis and is present in the blood of most patients with the disease. When the citrulline antibody is detected in a patient's blood, there is a 95% likelihood that the patient has rheumatoid arthritis.



The information in this article is not meant to be medical advice.�Treatment for a medical condition should come at the recommendation of your personal physician.

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