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Chronic Progressive External Ophthalmoplegia (CPEO) Print E-mail

Dr. Kennedy Chronic progressive external ophthalmoplegia (CPEO) is a disorder of the mitochondria, the tiny organelles in cells which produce energy. It is characterized by multiple mitochondrial DNA deletions in skeletal muscle, including the small muscles which direct the gaze of the eyes. The most common presentation is adult onset of weakness of the external eye muscles (ophthalmoplegia) and exercise intolerance. Other symptoms are variable, and may include loss of hearing, cataracts, sensory axonal neuropathy, ataxia, clinical depression, hypogonadism, and parkinsonism. Inheritance is by both autosomal dominant and autosomal recessive routes and is inherited exclusively from the mother. However, in most cases, CPEO occurs due to a sporadic deletion or duplication within the mitochondrial DNA. There is no mainstream medical treatment, however coenyzme Q-10 may provide benefit.



The information in this article is not meant to be medical advice.�Treatment for a medical condition should come at the recommendation of your personal physician.

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