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Choriocarcinoma Print E-mail

Dr. Kennedy Choriocarcinoma is a highly malignant tumor arising from trophoblasts (fetal cells which form part of the placenta along with maternal cells) within the uterus. Therefore, from a genetic standpoint, the mother is being invaded by cancer cells derived from the fetus. Choriocarcinoma tends to be invasive and to metastasize early and widely through both the venous and lymphatic systems.

Choriocarcinoma is one of the two types of gestational trophoblastic tumor, the other being hydatidiform mole ("molar pregnancy") (which results from over-production of the tissue that is supposed to develop into the placenta. Often, there is no fetus at all). Choriocarcinoma may follow any type of pregnancy. It is especially likely to occur with a hydatidiform mole. About 2 to 3% of hydatidiform moles are complicated by the development of choriocarcinoma.

The prognosis for women with metastatic choriocarcinoma was once grim. It has markedly improved with the advent of multidrug chemotherapy. Patients with high-risk metastatic disease usually need aggressive multidrug chemotherapy. Women with low-risk metastatic disease are sometimes treated with a single drug. Overall, the cure rate for high-risk patients is 60 to 80%.



The information in this article is not meant to be medical advice.�Treatment for a medical condition should come at the recommendation of your personal physician.

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