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Catecholamines [Epinephrine (Adrenalin) and Norepinephrine (Noradrenalin)] and Catechol-O-methyltransferase (COMT) Print E-mail

Dr. Kennedy Catecholamines - Pronounced cat·e·cole·a-means - are amines derived from the amino acid tyrosine - examples include epinephrine (adrenaline), norepinephrine (noradrenaline), and dopamine - that act as hormones and as neurotransmitters. There are a number of disorders involving catecholamines, including neuroblastoma, pheochromocytoma, chemodectina, the familial paraganglioma syndrome, dopamine-ß-hydroxalase deficiency, and tetrahydrobiopterin deficiency.

Catechol-O-methyltransferase (COMT) is an enzyme that catalyzes the degradation of the catecholamines, including the neurotransmitters dopamine (a precursor of norepinephrine), epinephrine, and norepinephrine. COMT is also important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson's disease.



The information in this article is not meant to be medical advice.�Treatment for a medical condition should come at the recommendation of your personal physician.

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