Cherubism is a genetic disorder of childhood causing prominence of the lower face and an appearance similar to the cherubs portrayed in Renaissance art. Cherubism is due to a problem in bone formation limited to the upper and lower jaws (the maxilla and mandible) with loss of bone in the jaws and its replacement by excessive amounts of fibrous tissue. These abnormalities often resolve after puberty. Cherubism is inherited as an autosomal dominant condition. Most boys and girls with it have a parent who had cherubism, while the few children with cherubism without a family history are thought to have a new mutation (a newly arisen gene) for cherubism but can transmit it to their children.